Product Info Summary
SKU: | A01959 |
---|---|
Size: | 100ul |
Reactive Species: | Human |
Host: | Rabbit |
Application: | IP, IHC, ICC, WB |
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Product info
Product Name
Anti-TRP1 TYRP1 Antibody
SKU/Catalog Number
A01959
Size
100ul
Form
Liquid
Description
Boster Bio Anti-TRP1 TYRP1 Antibody catalog # A01959. Tested in WB,ICC,IHC,IP applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-TRP1 TYRP1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01959)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human IBP5 protein.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A01959 is reactive to TYRP1 in Human
Applications
A01959 is guaranteed for IP, IHC, ICC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
60.724kDa
Background of TYRP1
Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 5 is a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin 5 seems to be involved proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. Cullin 5 may form a cell surface vasopressin receptor. Cullin 5 is part of a E3 ubiquitin ligase complex with elongin BC complex (TCEB1 and TCEB2), RBX1 and MUF1, complexes with elongin BC complex (TCEB1 and TCEB2), RXB1 and TCEB3 or SOCS1 or WSB1; elongin BC complex (TCEB1 and TCEB2), RBX1 and VHL; elongin BC complex (TCEB1 and TCEB2), RBX1, adenovirus type 5 E1B-55kDa protein and adenovirus type 5 E4-orf6. Cullin 5 Interacts with RBX1 and RNF7.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:2,000
ICC: 1:50-1:100
IHC: 1:50-1:200
IP: 1:10-1:50
Validation Images & Assay Conditions
Click image to see more details
Figure 2. Immunocytochemistry staining of TYRP1 using Anti-TRP1 TYRP1 Antibody (A01959).
ICC staining TRP1 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehydeClick image to see more details
Figure 1. Western blotting validation for Anti-TRP1 TYRP1 Antibody A01959
Western blot analysis of TRP1 on melanoma tissue lysate using anti-TRP1 antibody at 1/500 dilution.Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For TYRP1 (Source: Uniprot.org, NCBI)
Gene Name
TYRP1
Full Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
Weight
60.724kDa
Superfamily
tyrosinase family
Alternative Names
b-PROTEIN; CAS25,6-dihydroxyindole-2-carboxylic acid oxidase; Catalase B; CATB; EC 1.14.18; EC 1.14.18.-; EC 1.14.18.1; Glycoprotein 75; GP75DHICA oxidase; Melanoma antigen gp75; TRP-1; TRPTYRP; tyrosinase-related protein 1TRP1; TYRRP TYRP1 CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN tyrosinase related protein 1 5,6-dihydroxyindole-2-carboxylic acid oxidase|DHICA oxidase|catalase B|glycoprotein 75|melanoma antigen gp75
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TYRP1, check out the TYRP1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TYRP1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TRP1 TYRP1 Antibody (A01959)
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