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Product Info Summary
| SKU: | M01959 |
|---|---|
| Size: | 100ug/vial |
| Reactive Species: | Human, Mouse |
| Host: | Mouse |
| Application: | Flow Cytometry, IF, IHC |
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Product info
Product Name
Anti-Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Monoclonal Antibody
SKU/Catalog Number
M01959
Size
100ug/vial
Form
Liquid
Description
Boster Bio Anti-Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Monoclonal Antibody (Catalog # M01959). Tested in Flow Cytometry, IF, IHC applications. This antibody reacts with Human, Mouse.
Storage & Handling
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Cite This Product
Anti-Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01959)
Host
Mouse
Contents
Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Clonality
Monoclonal
Clone Number
Clone: SPM611
Isotype
IgG2a, kappa
Immunogen
Recombinant full-length human TYRP1 protein
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Does not cross-react with primate, avian or amphibian GR.
Reactive Species
M01959 is reactive to TYRP1 in Human, Mouse
Applications
M01959 is guaranteed for Flow Cytometry, IF, IHC Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
60.724kDa
Background of TYRP1
This monoclonal antibody reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Reconsitution
Reconstitute with distilled water.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Validation Images & Assay Conditions
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Formalin-fixed, paraffin-embedded human Melanoma stained with Anti-TYRP1 MAB (SPM611)
Protein Target Info & Infographic
Gene/Protein Information For TYRP1 (Source: Uniprot.org, NCBI)
Gene Name
TYRP1
Full Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
Weight
60.724kDa
Superfamily
tyrosinase family
Alternative Names
b-PROTEIN; CAS25,6-dihydroxyindole-2-carboxylic acid oxidase; Catalase B; CATB; EC 1.14.18; EC 1.14.18.-; EC 1.14.18.1; Glycoprotein 75; GP75DHICA oxidase; Melanoma antigen gp75; TRP-1; TRPTYRP; tyrosinase-related protein 1TRP1; TYRRP TYRP1 CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN tyrosinase related protein 1 5,6-dihydroxyindole-2-carboxylic acid oxidase|DHICA oxidase|catalase B|glycoprotein 75|melanoma antigen gp75
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TYRP1, check out the TYRP1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TYRP1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Monoclonal Antibody (M01959)
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No publications found for M01959
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