Product Info Summary
SKU: | A02598-4 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-Tyrosine-protein kinase JAK3 JAK3 Antibody
SKU/Catalog Number
A02598-4
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Tyrosine-protein kinase JAK3 JAK3 Antibody catalog # A02598-4. Tested in WB applications. This antibody reacts with Human,Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Tyrosine-protein kinase JAK3 JAK3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02598-4)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human B-Myb around the phosphorylation site of S577.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A02598-4 is reactive to JAK3 in Human, Mouse
Applications
A02598-4 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
125.099kDa
Background of JAK3
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
Tsai L.-H., Nature 371:419-423(1994).
Patrick G.N., Nature 402:615-622(1999).
Kesavapany S., J. Neurosci. 24:4421-4431(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:1,000
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunocytochemistry staining of JAK3 using Anti-Tyrosine-protein kinase JAK3 JAK3 Antibody (A02598-4).
ICC staining JAK3 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehydeClick image to see more details
Figure 2. Immunohistochemistry validation of JAK3 using Anti-Tyrosine-protein kinase JAK3 JAK3 Antibody (A02598-4).
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-JAK3 antibody. Counter stained with hematoxylin.For more protocol information of IHC
Protein Target Info & Infographic
Gene/Protein Information For JAK3 (Source: Uniprot.org, NCBI)
Gene Name
JAK3
Full Name
Tyrosine-protein kinase JAK3
Weight
125.099kDa
Superfamily
protein kinase superfamily
Alternative Names
EC 2.7.10; Jak3; JAK3_HUMAN; JAK-3EC 2.7.10.2; JAKL; JAKLtyrosine-protein kinase JAK3; Janus kinase 3Leukocyte janus kinase; LJAK; L-JAKJanus kinase 3 (a protein tyrosine kinase, leukocyte) JAK3 JAK-3_HUMAN, JAKL, L-JAK, LJAK, JAK3 Janus kinase 3 tyrosine-protein kinase JAK3|Janus kinase 3 (a protein tyrosine kinase, leukocyte)|leukocyte Janus kinase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on JAK3, check out the JAK3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for JAK3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Tyrosine-protein kinase JAK3 JAK3 Antibody (A02598-4)
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No publications found for A02598-4
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