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- Table of Contents
JAK3 Antibodies
AND JAK3 ELISA kits, JAK3 Proteins
Many biological assays use antibodies to detect JAK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with JAK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop JAK3 antibodies...
Designing a Western blot for JAK3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the JAK3 Western Blot GuideJAK3 Infographic by Boster Bio
All JAK3 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, IP, IF, WB
$146
Cat # M02598-2
20μL, 40μL, 100μL, 200μL
Cat # M02598-2
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$540
Cat # EKC2304
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2304
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1316
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1316
1 kit, containing one 96-well plate and all necessary reagents
JAK3 Overview
Facts about Tyrosine-protein kinase JAK3.
Tyrosine-protein kinase JAK3 (JAK3)
Non-receptor tyrosine kinase involved in various processes like cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development.
In the cytoplasm, plays a pivotal role in signal transduction through its association with type I receptors sharing the frequent subunit gamma like IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of this receptor, creating docking sites for STATs proteins.
Gene Information
| Human | |
|---|---|
| Gene Name: | JAK3 |
| Uniprot: | P52333 |
| Entrez: | 3718 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.10; Jak3; JAK3_HUMAN; JAK-3EC 2.7.10.2; JAKL; JAKLtyrosine-protein kinase JAK3; Janus kinase 3Leukocyte janus kinase; LJAK; L-JAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)
Molecular Weight
Mass (kDA):
125.099 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.11 |
| Sequence: | 19; NC_000019.10 (17824782..17848071, complement) |
Tissue Specificity
In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins.
Subcellular Localizations
Endomembrane system; Peripheral membrane protein. Cytoplasm.
Diseases
- Janiceps
- Severe Combined Immunodeficiency
- Malignant Neoplasms
- Immunologic Deficiency Syndromes
- Leukemia
- Neoplasms
- Congenital Combined Immunodeficiency
- Lymphoma
- Inflammation
- Autoimmune Reaction
- Carcinoma
- Decreased Immunologic Activity [pe]
- Autoimmune Diseases
Interacting Proteins
- KHDRBS1
- MAGED2
- NAP1L1
Pathways
- Cell Proliferation
- Pathogenesis
- Cell Growth
- Cell Cycle
- Cell Death
- Cell Development
- Secretion
- Cell Differentiation
- Immune Response
- Cell Activation
- T Cell Activation
- T Cell Proliferation
- Localization
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Methylation
- Ubiquitination
- Acetylation
Research Areas
- Cell Biology
- Protein Kinase
- Signal Transduction
- Tyrosine Kinases
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JAK3
bosterbio.com/bosterbio-gene-info-cards/JAK3
References
PMID: 8022790 by Kawamura M., et al. Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes.
PMID: 7559633 by Lai K.S., et al. A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells.
1 Publications of Boster JAK3 Antibodies & ELISA Kits
- PubMed ID: 25550894, Liu M, Yang S, Zhang D, Shui P, Song S, Yao J, Dai Y, Sun Q. Int J Clin Exp Med....
*More publications can be found for each product on its corresponding product page