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Product Info Summary
| SKU: | A12617 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-UCMA Antibody
SKU/Catalog Number
A12617
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-UCMA Antibody (Catalog # A12617). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
UCMA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-UCMA Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A12617)
Host
Rabbit
Contents
UCMA Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
UCMA antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human UCMA. The immunogen is located within the last 50 amino acids of UCMA.
Reactive Species
A12617 is reactive to UCMA in Human, Mouse
Observed Molecular Weight
68 kDa
Calculated molecular weight
16.6 kDa
Background of UCMA
UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A12617 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
UCMA antibody can be used for detection of UCMA by Western blot at 2.5 - 5 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of UCMA in SW1353 cell lysate with UCMA antibody at 2.5 μg/mL.
Specific Publications For Anti-UCMA Antibody (A12617)
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