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Product Info Summary
| SKU: | M04288 |
|---|---|
| Size: | 50 µl |
| Reactive Species: | African green monkey, Human |
| Host: | Mouse |
| Application: | WB |
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Product info
Product Name
Anti-USP2 Antibody
SKU/Catalog Number
M04288
Size
50 µl
Description
Boster Bio Anti-USP2 Antibody (Catalog # M04288). Tested in WB application(s). This antibody reacts with Human, African green monkey.
Storage & Handling
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Cite This Product
Anti-USP2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M04288)
Host
Mouse
Contents
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality
Monoclonal
Clone Number
1738CT331.50.87
Isotype
IgG1,k
Immunogen
This USP2 antibody is generated from a mouse immunized with a recombinant protein between 1-258 amino acids from human USP2.
Reactive Species
M04288 is reactive to USP2 in African green monkey, Human
Calculated molecular weight
68.1 kDa
Background of USP2
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M04288 is guaranteed for WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:2000
Validation Images & Assay Conditions
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All lanes : Anti-USP2 Antibody at 1:2000 dilution
Lane 1: MCF-7 whole cell lysate
Lane 2: PC-3 whole cell lysate
Lane 3: COS-7 whole cell lysate
Lane 4: Du145 whole cell lysate
Lane 5: SK-BR-3 whole cell lysate
Lysates/proteins at 20 µg per lane.
Secondary
Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.
Predicted band size : 68 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.
Specific Publications For Anti-USP2 Antibody (M04288)
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