Anti-Xaa-Pro aminopeptidase 2 XPNPEP2 Antibody

Product Name

Anti-Xaa-Pro aminopeptidase 2 XPNPEP2 Antibody

View all Aminopeptidase P2/XPNPEP2 Antibodies

SKU/Catalog Number

A09337

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Xaa-Pro aminopeptidase 2 XPNPEP2 Antibody catalog # A09337. Tested in WB applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Xaa-Pro aminopeptidase 2 XPNPEP2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09337)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human AAA1 protein.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A09337 is reactive to XPNPEP2 in Human, Mouse, Rat

Applications

A09337 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

75.625kDa

Background of Aminopeptidase P2/XPNPEP2

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.

Ota T., Nat. Genet. 36:40-45(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Trippe R.,RNA 12:1494-1504(2006).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:1000-1:2000

Validation Images & Assay Conditions

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Figure 1. Western blotting validation for Anti-Xaa-Pro aminopeptidase 2 XPNPEP2 Antibody A09337

Western blot analysis of extract of various cells

Gene/Protein Information For XPNPEP2 (Source: Uniprot.org, NCBI)

Alternative Names

Aminoacylproline aminopeptidase; Aminopeptidase P2; APP2; EC 3.4.11.9; mAmP; Membrane-bound aminopeptidase P; Membrane-bound AmP; Membrane-bound APP; xaa-Pro aminopeptidase 2; XPNPEP2; X-Pro aminopeptidase 2; X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound XPNPEP2 AEACEI, APP2 X-prolyl aminopeptidase 2 xaa-Pro aminopeptidase 2|X-Pro aminopeptidase 2|X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound|aminoacylproline aminopeptidase|mAmP|membrane-bound APP|membrane-bound AmP|membrane-bound aminopeptidase P

For more info on XPNPEP2, check out the XPNPEP2 Infographic

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In this infographic, you will see the following information for XPNPEP2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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