Product Info Summary
SKU: | A04648 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-Zinc finger MYM-type protein 2 ZMYM2 Antibody
SKU/Catalog Number
A04648
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Zinc finger MYM-type protein 2 ZMYM2 Antibody (Catalog # A04648). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
ZMYM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Zinc finger MYM-type protein 2 ZMYM2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04648)
Host
Rabbit
Contents
ZMYM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
ZMYM2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ZMYM2. The immunogen is located within amino acids 120 - 170 of ZMYM2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of ZMYM2 are known to exist; this antibody will detect only the longest isoform. ZMYM2 antibody is predicted to not cross-react with other ZMYM protein family members.
Reactive Species
A04648 is reactive to ZMYM2 in Human, Mouse, Rat
Applications
A04648 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
154.911kDa
Background of ZNF198
Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression (1). The protein folding and the DNA binding ability are governed by the coordination of a zinc ion (1-3). As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes (4). Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL) (5).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ZMYM2 antibody can be used for detection of ZMYM2 by Western blot at 0. 125 - 0.25 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ZMYM2 in EL4 cell lysate with ZMYM2 antibody at (A) 0.125 and (B) 0.25 μg/mL.
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Immunocytochemistry of ZMYM2 in HeLa cells with ZMYM2 antibody at 10 μg/mL.
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Immunofluorescence of ZMYM2 in HeLa cells with ZMYM2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For ZMYM2 (Source: Uniprot.org, NCBI)
Gene Name
ZMYM2
Full Name
Zinc finger MYM-type protein 2
Weight
154.911kDa
Alternative Names
FIMRAMPSCLL; Fused in myeloproliferative disorders protein; MYM; Rearranged in atypical myeloproliferative disorder protein; Zinc finger protein 198rearranged in an atypical myeloproliferative disorder; zinc finger, MYM-type 2; ZNF198zinc finger MYM-type protein 2 ZMYM2 FIM, MYM, RAMP, SCLL, ZNF198 zinc finger MYM-type containing 2 zinc finger MYM-type protein 2|fused in myeloproliferative disorders protein|rearranged in an atypical myeloproliferative disorder|zinc finger protein 198|zinc finger, MYM-type 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ZMYM2, check out the ZMYM2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ZMYM2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Zinc finger MYM-type protein 2 ZMYM2 Antibody (A04648)
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