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- Table of Contents
Facts about ATP-binding cassette sub-family D member 1.
Involved in many procedures; namely, controls the active myelination stage by negatively regulating the microsomal fatty acid elongation activity and could also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating adrenal function such as, mitochondrial oxidative phosphorylation and depolarization.
Human | |
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Gene Name: | ABCD1 |
Uniprot: | P33897 |
Entrez: | 215 |
Belongs to: |
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ABC transporter superfamily |
Adrenoleukodystrophy protein; ALDATP-binding cassette sub-family D member 1; ALDPadrenoleukodystrophy; AMNABC42; ATP-binding cassette, sub-family D (ALD), member 1
Mass (kDA):
82.937 kDA
Human | |
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Location: | Xq28 |
Sequence: | X; NC_000023.11 (153724851..153744755) |
Peroxisome membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
PMID: 8441467 by Mosser J., et al. Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters.
PMID: 10551832 by Liu L.X., et al. Homo- and heterodimerization of peroxisomal ATP-binding cassette half-transporters.