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- Table of Contents
Facts about Cis-aconitate decarboxylase.
Involved in antimicrobial response of innate immune cells; ACOD1- mediated itaconic acid generation contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.
Mouse | |
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Gene Name: | Acod1 |
Uniprot: | P54987 |
Entrez: | 16365 |
Belongs to: |
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PrpD family |
Cis-aconitate decarboxylase
Mass (kDA):
53.758 kDA
Mouse | |
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Location: | 14 E2.3|14 51.67 cM |
Sequence: | 14; |
Expressed in LPS-tolerized macrophages (at protein level). Expressed in the luminal epithelial cells of pregnant uterus. Expressed in microglia and macrophage cells.
PMID: 7721348 by Lee C.G.L., et al. Cloning and analysis of gene regulation of a novel LPS-inducible cDNA.
PMID: 14500577 by Cheon Y.P., et al. Immune-responsive gene 1 is a novel target of progesterone receptor and plays a critical role during implantation in the mouse.