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Involved in antimicrobial response of innate immune cells; ACOD1- mediated itaconic acid generation contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.
|Location:||14 E2.3|14 51.67 cM|
Expressed in LPS-tolerized macrophages (at protein level). Expressed in the luminal epithelial cells of pregnant uterus. Expressed in microglia and macrophage cells.