Cis-aconitate decarboxylase (Acod1)

Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages.

Involved in antimicrobial response of innate immune cells; ACOD1- mediated itaconic acid generation contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.