ACOT2 Antibodies

AND ACOT2 ELISA kits, ACOT2 Proteins

Many biological assays use antibodies to detect ACOT2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ACOT2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ACOT2 antibodies...

We validate the specificity of these antibodies to ACOT2 by testing them on tissues known to express ACOT2 positively and negatively. Browse below to find the ACOT2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for ACOT2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the ACOT2 IHC Guide

ACOT2 Infographic by Boster Bio

All ACOT2 Products

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Anti-ACOT2 Antibody

Immunohistochemistry validation of ACOT2 using Anti-ACOT2 Antibody (A10261-1)

Human, Mouse, Rat

ELISA, IF, IHC, WB

$380
Cat # A10261-1
100ul

ACOT2 Overview

Facts about Acyl-coenzyme A thioesterase 2, mitochondrial.

ACOT2 3D structure. Source: alphafold

Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2)

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.

Gene Information

Human
Gene Name:	ACOT2
Uniprot:	P49753
Entrez:	10965

Family

Belongs to:

C/M/P thioester hydrolase family

Alternative Names

acyl-CoA thioesterase 2MTE1; Acyl-coenzyme A thioester hydrolase 2a; acyl-coenzyme A thioesterase 2, mitochondrial; CTE-Ia; EC 3.1.2.2; Long-chain acyl-CoA thioesterase 2; mitochondrial acyl-CoA thioesterase 1; mitochondrial acyl-CoA thioesterase 2; peroxisomal long-chain acyl-coA thioesterase 2; PTE2A; PTE2CTE1A; ZAP128Mte1

Molecular Weight

Mass (kDA):
53.218 kDA

Genomic Context


Human

Location:	14q24.3
Sequence:	14; NC_000014.9 (73567620..73575658)

Tissue Specificity

Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.

Subcellular Localizations

Mitochondrion.

Diseases

Obesity
Neoplasms
Leydig Cell Tumor
Tumors Of Adrenal Cortex
Adrenal Hyperplasia
Posttransfusion Purpura
Infectious Mononucleosis
Deficiency Diseases
Impaired Cognition

Cognition Disorders
Hyperplasia
Medium-chain Acyl-coenzyme A Dehydrogenase Deficiency

Pathways

Fatty Acid Oxidation
Transport
Protein Phosphorylation
Regulation Of Cholesterol Transport
Peroxisome Localization
Fatty Acid Beta-oxidation
Cholesterol Transport

Localization
Excretion

PTMs

Phosphorylation

Oxidation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACOT2

References

PMID: 7596406 by Sherrington R., et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

PMID: 16940157 by Hunt M.C., et al. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.