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- Table of Contents
Facts about ADAMTS-like protein 3.
Human | |
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Gene Name: | ADAMTSL3 |
Uniprot: | P82987 |
Entrez: | 57188 |
Belongs to: |
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No superfamily |
ADAMTSL-3; ADAMTS-like 3; ADAMTS-like protein 3; KIAA1233a disintegrin-like and metalloprotease domain with thrombospondin type Imotifs-like 3; MGC150716; MGC150717; punctin-2
Mass (kDA):
188.692 kDA
Human | |
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Location: | 15q25.2 |
Sequence: | 15; NC_000015.10 (83654095..84039842) |
Expressed in epithelial cells of the colon, fallopian tube, skin, breast, prostate, epididymis, liver, pancreatic islets and bile ducts, as well as by vascular endothelial cells, smooth muscle cells, fibroblasts, cortical and ganglionic neurons and cardiac myocytes. Also expressed by malignant epithelial cells in colon cancer, as well as breast, prostate, renal and skin tumors. Expression is significantly reduced in colon cancer compared to normal colon.
Secreted, extracellular space, extracellular matrix.
PMID: 14667842 by Hall N.G., et al. ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases.
PMID: 17597111 by Koo B.H., et al. ADAMTSL3/punctin-2, a gene frequently mutated in colorectal tumors, is widely expressed in normal and malignant epithelial cells, vascular endothelial cells and other cell types, and its mRNA is reduced in colon cancer.