- Table of Content
Putative mitochondrial ATPase.Plays a role in mitochondrial morphology and mitochondrial protein metabolism.
Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and regular activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.
|AFG1 ATPase family|
|Location:||10 B2|10 22.88 cM|
Highly expressed in heart, kidney, and lactating breast. Present at reduced levels in virgin, pregnant, and involuting breast.