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- Table of Contents
Facts about Cytosolic carboxypeptidase 4.
Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.
Human | |
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Gene Name: | AGBL1 |
Uniprot: | Q96MI9 |
Entrez: | 123624 |
Belongs to: |
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peptidase M14 family |
Cytosolic carboxypeptidase 4
Mass (kDA):
125.33 kDA
Human | |
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Location: | 15q25.3 |
Sequence: | 15; NC_000015.10 (86079620..87031476) |
Expressed in corneal endothelium.
Cytoplasm, cytosol.
PMID: 24094747 by Riazuddin S.A., et al. Mutations in AGBL1 cause dominant late-onset Fuchs corneal dystrophy and alter protein-protein interaction with TCF4.