AGBL1 Antibodies

AND AGBL1 ELISA kits, AGBL1 Proteins

Many biological assays use antibodies to detect AGBL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AGBL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AGBL1 antibodies...

We validate the specificity of these antibodies to AGBL1 by testing them on tissues known to express AGBL1 positively and negatively. Browse below to find the AGBL1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AGBL1 Infographic by Boster Bio

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AGBL1 Overview

Facts about Cytosolic carboxypeptidase 4.

AGBL1 3D structure. Source: alphafold

Cytosolic carboxypeptidase 4 (AGBL1)

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins.

Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.

Gene Information

Human
Gene Name:	AGBL1
Uniprot:	Q96MI9
Entrez:	123624

Family

Belongs to:

peptidase M14 family

Alternative Names

Cytosolic carboxypeptidase 4

Molecular Weight

Mass (kDA):
125.33 kDA

Genomic Context


Human

Location:	15q25.3
Sequence:	15; NC_000015.10 (86079620..87031476)

Tissue Specificity

Expressed in corneal endothelium.

Subcellular Localizations

Cytoplasm, cytosol.

Diseases

Corneal dystrophy, Fuchs endothelial, 8 (FECD8)

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AGBL1

References

PMID: 24094747 by Riazuddin S.A., et al. Mutations in AGBL1 cause dominant late-onset Fuchs corneal dystrophy and alter protein-protein interaction with TCF4.