AGBL5 Antibodies

AND AGBL5 ELISA kits, AGBL5 Proteins

Many biological assays use antibodies to detect AGBL5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AGBL5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AGBL5 antibodies...

We validate the specificity of these antibodies to AGBL5 by testing them on tissues known to express AGBL5 positively and negatively. Browse below to find the AGBL5 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AGBL5 Infographic by Boster Bio

All AGBL5 Products

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AGBL5 (NM_021831) Human Recombinant Protein

Coomassie blue staining of purified AGBL5 protein

$1062
Cat # PROTQ8NDL9
20 µg

AGBL5 (NM_021831) Human Over-expression Lysate

Human

$960
Cat # LS060509
20 µg, 100 µg

AGBL5 Overview

Facts about Cytosolic carboxypeptidase-like protein 5.

AGBL5 3D structure. Source: alphafold

Cytosolic carboxypeptidase-like protein 5 (AGBL5)

Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of this branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins.

In contrast, it's not able to serve as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS.

Gene Information

Human
Gene Name:	AGBL5
Uniprot:	Q8NDL9
Entrez:	60509

Family

Belongs to:

peptidase M14 family

Alternative Names

ATP/GTP binding protein-like 5; ATP/GTP-binding protein-like 5; CCP5; cytosolic carboxypeptidase-like protein 5; EC 3.4.17.-; FLJ21839

Molecular Weight

Mass (kDA):
97.534 kDA

Genomic Context


Human

Location:	2p23.3
Sequence:	2; NC_000002.12 (27051423..27070622)

Tissue Specificity

Expressed in brain.

Subcellular Localizations

Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis.

Diseases

Retinitis pigmentosa 75 (RP75)

PTMs

Phosphoprotein

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AGBL5

References

PMID: 23085998 by Rodriguez de la Vega Otazo M., et al. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs).

PMID: 26720455 by Kastner S., et al. Exome Sequencing Reveals AGBL5 as Novel Candidate Gene and Additional Variants for Retinitis Pigmentosa in Five Turkish Families.