Cytosolic carboxypeptidase-like protein 5 (AGBL5)

Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of this branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins.

In contrast, it's not able to serve as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS.