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- Table of Contents
Facts about Cytosolic carboxypeptidase-like protein 5.
In contrast, it's not able to serve as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS.
Human | |
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Gene Name: | AGBL5 |
Uniprot: | Q8NDL9 |
Entrez: | 60509 |
Belongs to: |
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peptidase M14 family |
ATP/GTP binding protein-like 5; ATP/GTP-binding protein-like 5; CCP5; cytosolic carboxypeptidase-like protein 5; EC 3.4.17.-; FLJ21839
Mass (kDA):
97.534 kDA
Human | |
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Location: | 2p23.3 |
Sequence: | 2; NC_000002.12 (27051423..27070622) |
Expressed in brain.
Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis.
PMID: 23085998 by Rodriguez de la Vega Otazo M., et al. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs).
PMID: 26720455 by Kastner S., et al. Exome Sequencing Reveals AGBL5 as Novel Candidate Gene and Additional Variants for Retinitis Pigmentosa in Five Turkish Families.