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- Table of Contents
Autoimmune regulator Antibodies
AND AIRE ELISA kits, Autoimmune regulator Proteins
Many biological assays use antibodies to detect Autoimmune regulator, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Autoimmune regulator in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Autoimmune regulator antibodies...
Designing a Western blot for Autoimmune regulator? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the AIRE Western Blot GuideAIRE Infographic by Boster Bio
All AIRE Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9980
100 μg/vial
Cat # PB9980
100 μg/vial
Human, Mouse
ELISA
$480
Cat # EKC1020
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1020
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA
$540
Cat # EKC2603
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2603
1 kit, containing two 96-well plates and all necessary reagents
AIRE Overview
Facts about Autoimmune regulator.
Autoimmune regulator (AIRE)
Transcription factor playing an essential role to advertise self-tolerance from the thymus by regulating the expression of a wide selection of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich surroundings; the preferred theme is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box.
Binds into nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated in'Lys-4', not phosphorylated in'Thr-3' rather than methylated in'Arg-2'.
Gene Information
| Human | |
|---|---|
| Gene Name: | AIRE |
| Uniprot: | O43918 |
| Entrez: | 326 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AIRE; APECED protein; APECED; APECEDAPSI; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; autoimmune regulator (APECED protein)10APS1AIRE1; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermaldystrophy); Autoimmune Regulator; PGA1
Molecular Weight
Mass (kDA):
57.727 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.3 |
| Sequence: | 21; NC_000021.9 (44285876..44298648) |
Tissue Specificity
Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. In secondary lymphoid organs, expressed in a discrete population of bone marrow-derived toleregenic antigen presenting cells (APCs) called extrathymic AIRE expressing cells (eTAC)(at protein level) (PubMed:23993652). Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.
Subcellular Localizations
Nucleus. Cytoplasm. Predominantly nuclear but also cytoplasmic (PubMed:11274163, PubMed:14974083). Found in nuclear body-like structures (dots) and in a filamentous vimentin-like pattern (PubMed:11274163, PubMed:14974083, PubMed:26084028). Associated with tubular structures (PubMed:11274163, PubMed:14974083).
Diseases
- Autoimmune Reaction
- Polyendocrinopathies, Autoimmune
- Autoimmune Diseases
- Polyglandular Type I Autoimmune Syndrome
- Autoimmunity
- Dystrophy
- Candidiasis
- Immunologic Tolerance
- Diabetes Mellitus
- Hypoparathyroidism
- Autoimmune Polyendocrinopathy Syndrome, Type 1
- Diabetes Mellitus, Insulin-dependent
Interacting Proteins
- DAXX
- HIST1H3A
- NCK1
- PRKDC
Pathways
- Pathogenesis
- Tolerance Induction
- Localization
- Cell Development
- Methylation
- Central Tolerance Induction
- Immune Response
- Transport
- Cell Death
- Secretion
- Keratinization
- Cell Activation
- T Cell Activation
PTMs
- Methylation
- Phosphorylation
- Cleavage
- Acetylation
Research Areas
- Immune System Diseases
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AIRE
bosterbio.com/bosterbio-gene-info-cards/AIRE
References
PMID: 9398839 by Nagamine K., et al. Positional cloning of the APECED gene.
PMID: 9398840 by Aaltonen J., et al. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains.