Autoimmune regulator (AIRE)

Transcription factor playing an essential role to advertise self-tolerance from the thymus by regulating the expression of a wide selection of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich surroundings; the preferred theme is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box.

Binds into nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated in'Lys-4', not phosphorylated in'Thr-3' rather than methylated in'Arg-2'.