A-kinase anchor protein 13 (AKAP13)

Scaffold protein that plays an significant role in assembling signaling complexes downstream of several kinds of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors through its role as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829).

May also activate other Rho family members (PubMed:11546812). Section of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381).