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- Table of Contents
AKR1C3 Antibodies
AND AKR1C3 ELISA kits, AKR1C3 Proteins
Many biological assays use antibodies to detect AKR1C3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AKR1C3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AKR1C3 antibodies...
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AKR1C3 Infographic by Boster Bio
All AKR1C3 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK1869
96 wells/kit, with removable strips.
Cat # EK1869
96 wells/kit, with removable strips.
Enzyme Activity, SDS-PAGE
$250
Cat # PROTP42330
Starting from 20ug
Cat # PROTP42330
Starting from 20ug
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M01820
100 μl/vial
Cat # M01820
100 μl/vial
AKR1C3 Overview
Facts about Aldo-keto reductase family 1 member C3.
Aldo-keto reductase family 1 member C3 (AKR1C3)
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2.
Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites.
Gene Information
| Human | |
|---|---|
| Gene Name: | AKR1C3 |
| Uniprot: | P42330 |
| Entrez: | 8644 |
Family
| Belongs to: |
|---|
| aldo/keto reductase family |
Alternative Names
17-beta-hydroxysteroid dehydrogenase type 5; 3-alpha-HSD type 2; 3-alpha-hydroxysteroid dehydrogenase type 2; AKR1C3; Aldo-keto Reductase 1C3; aldo-keto reductase family 1 member C3; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); AldoketoReductase 1C3; Chlordecone reductase homolog HAKRb; DD3; DD-3; DD317-beta-HSD 5; DDH1; DDX; Dihydrodiol dehydrogenase 3; Dihydrodiol dehydrogenase type I; dihydrodiol dehydrogenase X; EC 1.1.1; EC 1.1.1.112,3-alpha-HSD type II, brain; EC 1.1.1.188; EC 1.1.1.213; EC 1.1.1.63; EC 1.1.1.64; EC 1.3.1.20; HA1753; HAKRB; HAK
Molecular Weight
Mass (kDA):
36.853 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10p15.1 |
| Sequence: | 10; NC_000010.11 (5048766..5107686) |
Tissue Specificity
Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Prostate
- Neoplasms
- Prostatic Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Endometrial Polyp
- Leukemia
- Obesity
- Adenocarcinoma
- Carcinogenesis
- Hyperplasia
Pathways
- Cell Proliferation
- Localization
- Pathogenesis
- Cell Cycle
- Cell Differentiation
- Cell Growth
- Secretion
- Transport
- Parturition
- Drug Resistance
- Cell Death
- Gene Silencing
- Aging
PTMs
- Reduction
- Oxidation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AKR1C3
bosterbio.com/bosterbio-gene-info-cards/AKR1C3
References
PMID: 8274401 by Qin K.-N., et al. Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.
PMID: 7650035 by Khanna M., et al. Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.