RAC-alpha serine/threonine-protein kinase (AKT1)

This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported up to now, but for most of them, no isoform specificity has been reported.

AKT accounts for the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 sugar transporter to the cell surface. Phosphorylation of PTPN1 in'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling.