ALAS2 Antibodies

AND ALAS2 ELISA kits, ALAS2 Proteins

Many biological assays use antibodies to detect ALAS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ALAS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ALAS2 antibodies...

We validate the specificity of these antibodies to ALAS2 by testing them on tissues known to express ALAS2 positively and negatively. Browse below to find the ALAS2 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ALAS2 Infographic by Boster Bio

All ALAS2 Products

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Specificity

Applications

Price

Anti-ALAS2 Antibody

Western blot analysis of extracts of various cell lines, using ALAS2 antibody at 1:1000 dilution

Human, Mouse, Rat

$405
Cat # A02525
100ul

Anti-ALAS2 Mouse Monoclonal Antibody [Clone ID: OTI2D3]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ALAS2 (Right lane) cDNA for 48 hrs and lysed

Human, Mouse, Rat

$523
Cat # M02525
100 µl

Anti-ALAS2/ASB Antibody Picoband®

Western blot analysis of ALAS2/ASB using anti-ALAS2/ASB antibody (A02525-1)

IF analysis of ALAS2/ASB using anti-ALAS2/ASB antibody (A02525-1)

Flow Cytometry analysis of K562 cells using anti-ALAS2/ASB antibody (A02525-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A02525-1
100 μg/vial

ALAS2 (NM_001037967) Human Over-expression Lysate

ALAS2 Human Over-expression Lysates NM_000032

Human

$628
Cat # LS000212
20 µg, 100 µg

Anti-Zebrafish ALAS2 Antibody Picoband®

Western blot analysis of ALAS2 using anti-ALAS2 antibody (AZQ9YHT4)

Zebrafish

$470
Cat # AZQ9YHT4
100 μg/vial

ALAS2 Overview

Facts about 5-aminolevulinate synthase, erythroid-specific, mitochondrial.

ALAS2 3D structure. Source: alphafold

5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)

Gene Information

Human
Gene Name:	ALAS2
Uniprot:	P22557
Entrez:	212

Family

Belongs to:

class-II pyridoxal-phosphate-dependent aminotransferase family

Alternative Names

5-aminolevulinic acid synthase 2,5-aminolevulinate synthase, erythroid-specific, mitochondrial; ALASE; ALAS-E; aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia); aminolevulinate, delta-, synthase 2; ANH1; ASBXLDPP; Delta-ALA synthase 2; delta-ALA synthetase; Delta-aminolevulinate synthase 2; EC 2.3.1.37; FLJ93603; XLSA

Molecular Weight

Mass (kDA):
64.633 kDA

Genomic Context


Human

Location:	Xp11.21
Sequence:	X; NC_000023.11 (55009055..55030977, complement)

Tissue Specificity

Erythroid specific.

Subcellular Localizations

Mitochondrion matrix.

Diseases

Anemia
Sideroblastic Anemia
Hereditary Sideroblastic Anemia
Iron Overload
Erythropoietic Protoporphyria
Genetic Diseases, X-linked
Microcytic Anemia
Refractory Anemias
Disorders Of Porphyrin Metabolism
Hypoxia
Hemochromatosis
Pyridoxine-responsive Sideroblastic Anemia

Secondary Acquired Sideroblastic Anemia
Ataxia
Refractory Anemia With Ringed Sideroblasts
Liver Diseases
Acute Erythroblastic Leukemia
Hypochromic Anemia

Interacting Proteins

BANP

Pathways

Pathogenesis
Localization
Translation
Cell Differentiation
Transport
Oxidative Phosphorylation
Reverse Transcription
Cell Proliferation
Intestinal Absorption
Response To Oxidative Stress
Cell Division
Phagocytosis
Mating

Cognition
Oxygen Transport
Iron-sulfur Cluster Assembly
Chromatin Remodeling
Histone Deacetylation
Dna Methylation
Metaphase

PTMs

Acetylation
Phosphorylation
Reduction

Hydroxylation
Methylation
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ALAS2

References

PMID: 2263504 by Bishop D.F.; Two different genes encode delta-aminolevulinate synthase in humans: nucleotide sequences of cDNAs for the housekeeping and erythroid genes.

PMID: 2050125 by Cox T.C., et al. Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA.