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- Table of Contents
Facts about Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase.
When coupled to KCNH2 may decrease KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (PubMed:14525949). Has a role in maintenance of cochlear outer hair cell function (By similarity).
Human | |
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Gene Name: | ALG10B |
Uniprot: | Q5I7T1 |
Entrez: | 144245 |
Belongs to: |
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ALG10 glucosyltransferase family |
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Mass (kDA):
55.448 kDA
Human | |
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Location: | 12q12 |
Sequence: | 12; NC_000012.12 (38316679..38329725) |
Highly expressed in heart, placenta, liver, kidney and pancreas. Weakly expressed in lung, skeletal muscle and brain.
Cell membrane; Multi-pass membrane protein.
PMID: 14525949 by Kupershmidt S., et al. The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.
PMID: 15280551 by Petersen C.I., et al. In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.