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- Table of Contents
Facts about APC membrane recruitment protein 1.
Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also functions as a negative regulator by acting as a scaffold protein to the beta- catenin destruction complex and promoting stabilization of Axin in the cell membrane.
Mouse | |
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Gene Name: | Amer1 |
Uniprot: | Q7TS75 |
Entrez: | 72345 |
Belongs to: |
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Amer family |
AMER1; FAM123B; OSCS; WTX
Mass (kDA):
124.164 kDA
Mouse | |
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Location: | X|X C3 |
Sequence: | X; |
Expressed in kidney.
PMID: 17204608 by Rivera M.N., et al. An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.