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- Table of Contents
Facts about APC membrane recruitment protein 1.
Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also functions as a negative regulator by acting as a scaffold protein to the beta- catenin destruction complex and promoting stabilization of Axin in the cell membrane.
| Mouse | |
|---|---|
| Gene Name: | Amer1 |
| Uniprot: | Q7TS75 |
| Entrez: | 72345 |

| Belongs to: |
|---|
| Amer family |

AMER1; FAM123B; OSCS; WTX
Mass (kDA):
124.164 kDA

| Mouse | |
|---|---|
| Location: | X|X C3 |
| Sequence: | X; |
Expressed in kidney.



PMID: 17204608 by Rivera M.N., et al. An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.