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Anoctamin-3 Antibodies

AND ANO3 ELISA kits, Anoctamin-3 Proteins

Many biological assays use antibodies to detect Anoctamin-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Anoctamin-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Anoctamin-3 antibodies...

We validate the specificity of these antibodies to Anoctamin-3 by testing them on tissues known to express ANO3 positively and negatively. Browse below to find the ANO3 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ANO3 Infographic by Boster Bio

ANO3 protein infographic

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ANO3 Overview

Facts about Anoctamin-3.

ANO3 3D structure

ANO3 3D structure. Source: alphafold

Anoctamin-3 (ANO3)

Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Appears to act as potassium channel regulator and might inhibit pain signaling; can ease KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by raising its sodium sensitivity (By similarity).

Doesn't exhibit calcium-activated chloride channel (CaCC) activity. .

Gene Information

Human
Gene Name:	ANO3
Uniprot:	Q9BYT9
Entrez:	63982

Gene Information

Family

Belongs to:

anoctamin family

Family

Alternative Names

anoctamin 3; anoctamin-3; C11orf25; GENX-3947; TMEM16C

Molecular Weight

Mass (kDA):
114.657 kDA

Molecular Weight

Genomic Context


Human

Location:	11p14.3-p14.2
Sequence:	11; NC_000011.10 (26189123..26667907)

Tissue Specificity

Highly expressed in the forebrain striatum.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Shows an intracellular localization.

Subcellular Localization

Diseases

Retinoblastoma
Asthma
Dystonia Disorders
Tissue Adhesions
Alzheimer's Disease
Eczema

Dysequilibrium Syndrome

Disease

Pathways

Cell Adhesion
Immune Response
Endocytosis
Pathogenesis

Pathways

PTMs

Nitration

Decarboxylation

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ANO3

References

PMID: 21642943 by Duran C., et al. Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?

PMID: 21607626 by Kunzelmann K., et al. Anoctamins.