- Table of Content
Drives internalization of the APLNR (By similarity). Acts as a motogen by boosting mesendodermal cell migration during gastrulation by binding and activating APLNR (By similarity).
Expressed in the placenta (PubMed:28663440). Expressed in syncytiotrophoblasts of the placenta labyrinth at 10.5 dpc (PubMed:28663440). Expressed in placental chorionic trophoblasts (at protein level) (PubMed:28663440). Expressed in a small population of epiblast cells in the distal half of the embryo at 7 dpc (PubMed:20153842, PubMed:28854362). Expressed in newly formed definitive endoderm cells in the proximal half of the embryo, while it is not present in extra-embryonic endoderm at 7.5 dpc (PubMed:20153842, PubMed:28854362). This expression pattern then changes to the ventral aspect of the developing foregut pocket and the entire hindgut pocket at 8.5 dpc, before becoming restricted to the foregut overlying the heart and the posterior- most hindgut (PubMed:20153842). Not detected in endothelial precursor cells of the yolk sac at 8 dpc (PubMed:28663440). Expressed in extraembryonic tissues as well as in the chorion at 8.25 dpc (PubMed:28854362). Expressed in endometrial stroma of the uterus of pregnant mice at 8.5 dpc (PubMed:28663440). Expressed in the developing heart, caudal neural tube and trophobasts at 9 dpc (PubMed:28663440). Expressed in the chorionic plate of the chorio