Apelin receptor early endogenous ligand (Apela)

Endogenous ligand for the apelin receptor (APLNR) (By similarity). Hormone required for mesendodermal distinction, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis (PubMed:28371822, PubMed:28854362, PubMed:28890073, PubMed:28663440).

Drives internalization of the APLNR (By similarity). Acts as a motogen by boosting mesendodermal cell migration during gastrulation by binding and activating APLNR (By similarity).