Gamma-secretase subunit APH-1B (APH1B)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It likely represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.

Probably present in a minority of gamma-secretase complexes compared to APH1A. .