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- Table of Contents
Facts about Gamma-secretase subunit APH-1B.
Probably present in a minority of gamma-secretase complexes compared to APH1A. .
Human | |
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Gene Name: | APH1B |
Uniprot: | Q8WW43 |
Entrez: | 83464 |
Belongs to: |
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APH-1 family |
anterior pharynx defective 1 homolog B (C. elegans); APH1B; PSFL
Mass (kDA):
28.46 kDA
Human | |
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Location: | 15q22.2 |
Sequence: | 15; NC_000015.10 (63277550..63309126) |
Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain.
Membrane; Multi-pass membrane protein.
PMID: 15823552 by Saito S., et al. Identification and characterization of a novel human APH-1b splice variant lacking exon 4.
PMID: 12297508 by Lee S.-F., et al. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.