Aprataxin and PNK-like factor (Aplf)

Nuclease involved with single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently in sites of chromosomal damage to accelerate DNA strand break repair reactions.

Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks in hydroxyuracil and other types of pyrimidine base damage (By similarity).