Coatomer subunit delta (ARCN1)

Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transportation of dilysine-tagged proteins.

In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are little GTP-binding proteins; the complex also influences the Golgi structural integrity, in addition to the processing, activity, and endocytic recycling of LDL receptors (By similarity). .