ARFGEF3 Antibodies

AND ARFGEF3 ELISA kits, ARFGEF3 Proteins

Many biological assays use antibodies to detect ARFGEF3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARFGEF3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARFGEF3 antibodies...

We validate the specificity of these antibodies to ARFGEF3 by testing them on tissues known to express ARFGEF3 positively and negatively. Browse below to find the ARFGEF3 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ARFGEF3 Infographic by Boster Bio

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ARFGEF3 Overview

Facts about Brefeldin A-inhibited guanine nucleotide-exchange protein 3.

ARFGEF3 3D structure. Source: alphafold

Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF3)

Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity).

Inhibits nuclear translocation of the transcriptional coregulator PHB2 and might enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). .

Gene Information

Human
Gene Name:	ARFGEF3
Uniprot:	Q5TH69
Entrez:	57221

Family

Belongs to:

No superfamily

Alternative Names

Brefeldin A-inhibited guanine nucleotide-exchange protein 3

Molecular Weight

Mass (kDA):
240.652 kDA

Genomic Context


Human

Location:	6q23.3-q24.1
Sequence:	6; NC_000006.12 (138161690..138344663)

Subcellular Localizations

Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein.

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARFGEF3

References

PMID: 19496786 by Kim J.W., et al. Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer.