Rho GTPase-activating protein 10 (Arhgap10)

GTPase activator for the small GTPases RhoA and Cdc42 by turning them into an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases.

Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.