Rho GDP-dissociation inhibitor 3 (ARHGDIG)

Inhibits GDP/GTP exchange reaction of RhoB.

Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which reveal a growth-regulated expression in mammalian cells.

Stimulates the release of this GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.