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- Table of Contents
Facts about Rho GDP-dissociation inhibitor 3.
Inhibits GDP/GTP exchange reaction of RhoB.
Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which reveal a growth-regulated expression in mammalian cells.Stimulates the release of this GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.
Human | |
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Gene Name: | ARHGDIG |
Uniprot: | Q99819 |
Entrez: | 398 |
Belongs to: |
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Rho GDI family |
Rho GDI 3; Rho GDP dissociation inhibitor (GDI) gamma; rho GDP-dissociation inhibitor 3; RhoGDI gamma; Rho-GDI gamma; RHOGDI-3
Mass (kDA):
25.098 kDA
Human | |
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Location: | 16p13.3 |
Sequence: | 16; NC_000016.10 (280591..283010) |
Primarily expressed in pancreas and brain.
Cytoplasm.
PMID: 9113980 by Adra C.N., et al. RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas.
PMID: 9787082 by Adra C.N., et al. Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3.