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- Table of Contents
ATF4 Antibodies
AND ATF4 ELISA kits, ATF4 Proteins
Many biological assays use antibodies to detect ATF4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATF4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATF4 antibodies...
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ATF4 Infographic by Boster Bio
All ATF4 Products
Product
Figures
Specificity
Applications
Price
Anti-ATF4 Rabbit Monoclonal Antibody
4 Citations 17 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00371
100 μl
Cat # M00371
100 μl
Anti-ATF4 Antibody Picoband®
2 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00371-4
100 µg/vial
Cat # A00371-4
100 µg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00371-2
20μL, 40μL, 100μL, 200μL
Cat # M00371-2
20μL, 40μL, 100μL, 200μL
ATF4 Overview
Facts about Cyclic AMP-dependent transcription factor ATF-4.
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
Transcriptional activator. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decline in insulin production (By similarity).
It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress.
Gene Information
| Human | |
|---|---|
| Gene Name: | ATF4 |
| Uniprot: | P18848 |
| Entrez: | 468 |
Family
| Belongs to: |
|---|
| bZIP family |
Alternative Names
activating transcription factor 4 (tax-responsive enhancer element B67); Activating transcription factor 4; ATF4; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB-2DNA-binding protein TAXREB67; cyclic AMP-dependent transcription factor ATF-4; Cyclic AMP-responsive element-binding protein 2; TAXREB67; TAXREB67CREB2cAMP response element-binding protein 2; Tax-responsive enhancer element-binding protein 67; TXREB
Molecular Weight
Mass (kDA):
38.59 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.1 |
| Sequence: | 22; NC_000022.11 (39514494..39522686) |
Subcellular Localizations
Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783).
Diseases
- Endoplasmic Reticulum Stress
- Malignant Neoplasms
- Neoplasms
- Physiological Stress
- Hypoxia
- Diabetes Mellitus
- Inflammation
- Carcinoma
- Leukemia
- Liver Carcinoma
- Nervousness
- Mammary Neoplasms
Interacting Proteins
- ATF3
- BFSP2
- BTRC
- CCDC106
- CEBPA
- CEBPB
- CEBPD
- CEBPG
- CREBZF
- Dapk3
Pathways
- Translation
- Cell Death
- Osteoblast Differentiation
- Cell Cycle
- Pathogenesis
- Autophagy
- Secretion
- Cell Growth
- Transport
- Cell Proliferation
- Rna Interference
- Proteolysis
- Angiogenesis
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
- Acetylation
- Ubiquitination
- Oxidation
Research Areas
- Lipid and Metabolism
- Phospho-Specific
- Unfolded Protein Response
- Unfolded Protein Response (UPR)
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATF4
bosterbio.com/bosterbio-gene-info-cards/ATF4
References
PMID: 1847461 by Tsujimoto A., et al. Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I.
PMID: 1534408 by Karpinski B.A., et al. Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.
1 Publications of Boster ATF4 Antibodies & ELISA Kits
- PubMed ID: 23826386, MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylati...
*More publications can be found for each product on its corresponding product page