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- Table of Contents
ATP7B Antibodies
AND ATP7B ELISA kits, ATP7B Proteins
Many biological assays use antibodies to detect ATP7B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATP7B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATP7B antibodies...
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ATP7B Infographic by Boster Bio
All ATP7B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC
$380
Cat # A00686-1
100ul
Cat # A00686-1
100ul
Anti-ATP7b Rabbit Monoclonal Antibody
2 Citations
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # M00686
100 μl/vial
Cat # M00686
100 μl/vial
Anti-ATP7B Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, IF, ICC, WB
$370
Cat # A00686-2
100 μg/vial
Cat # A00686-2
100 μg/vial
ATP7B Overview
Facts about Copper-transporting ATPase 2.
Copper-transporting ATPase 2 (ATP7B)
Copper ion transmembrane transporter involved in the export of copper from the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | ATP7B |
| Uniprot: | P35670 |
| Entrez: | 540 |
Family
| Belongs to: |
|---|
| cation transport ATPase (P-type) (TC 3.A.3) family |
Alternative Names
ATPase, Cu(2+)- transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide; Copper pump 2; copper-transporting ATPase 2; EC 3.6.3; EC 3.6.3.4; PWD; WC1; WD; Wilson disease-associated protein; WNDATPase, Cu++ transporting, beta polypeptide (Wilson disease)
Molecular Weight
Mass (kDA):
157.263 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q14.3 |
| Sequence: | 13; NC_000013.11 (51932669..52012130, complement) |
Tissue Specificity
Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues.
Subcellular Localizations
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome. Predominantly found in the trans-Golgi network (TGN). Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed:10942420).; [Isoform 1]: Golgi apparatus membrane; Multi-pass membrane protein.; [Isoform 2]: Cytoplasm.; [WND/140 kDa]: Mitochondrion.
Diseases
- Hepatolenticular Degeneration
- Menkes Kinky Hair Syndrome
- Liver Diseases
- Copper Metabolism Disorder
- Malignant Neoplasms
- Poisoning Syndrome
- Carcinoma
- Liver Cirrhosis
- Neoplasms
- Hereditary Diseases
- Hepatitis
- Liver Failure
- Liver Carcinoma
Interacting Proteins
- ATOX1
- COMMD1
Pathways
- Transport
- Excretion
- Localization
- Pathogenesis
- Secretion
- Secretory Pathway
- Drug Resistance
- Lactation
- Cellular Localization
- Cell Death
- Cell Cycle
- Cell Proliferation
- Proteolysis
PTMs
- Phosphorylation
- Oxidation
- Amidation
- Cleavage
- Glutathionylation
Research Areas
- Cancer
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATP7B
bosterbio.com/bosterbio-gene-info-cards/ATP7B
References
PMID: 7833924 by Petrukhin K., et al. Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: genomic organization, alternative splicing, and structure/function predictions.
PMID: 10334941 by Oh W.J., et al. Cloning and characterization of the promoter region of the Wilson disease gene.
2 Publications of Boster ATP7B Antibodies & ELISA Kits
- PubMed ID: 10.3748/wjg.v12.i47.7695, Expression of ATP7B in human gastric cardiac carcinomas in comparison with dista...
- PubMed ID: 17171802, Wu Dl, Yi Hx, Sui Fy, Jiang Xh, Jiang Xm, Zhao Yy. World J Gastroenterol. 2006 D...
*More publications can be found for each product on its corresponding product page