Ataxin-7-like protein 3 (ATXN7L3)

Part of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that especially deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879).

The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972).