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- Table of Contents
Axin-1 Antibodies
AND AXIN1 ELISA kits, Axin-1 Proteins
Many biological assays use antibodies to detect Axin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Axin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Axin-1 antibodies...
Designing a Western blot for Axin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the AXIN1 Western Blot GuideAXIN1 Infographic by Boster Bio
All AXIN1 Products
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AXIN1 Overview
Facts about Axin-1.
Axin-1 (AXIN1)
Part of the beta-catenin destruction complex necessary for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by sparking a Wnt-independent JNK signaling pathway (PubMed:12192039).
Likely to be a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693).
Gene Information
| Human | |
|---|---|
| Gene Name: | AXIN1 |
| Uniprot: | O15169 |
| Entrez: | 8312 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
axin 1; Axin1; Axin-1; AXINaxis inhibitor 1; Axis inhibition protein 1; fused, mouse, homolog of; hAxin; MGC52315
Molecular Weight
Mass (kDA):
95.635 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (287440..355226, complement) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Cytoplasm. Nucleus. Membrane. Cell membrane. MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX (PubMed:17210684).
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Adenomatous Polyposis Coli
- Polyposis
- Carcinogenesis
- Cell Transformation, Neoplastic
- Liver Carcinoma
- Liver Neoplasms
- Colorectal Cancer
- Colorectal Neoplasms
- Malignant Tumor Of Colon
- Malignant Paraganglionic Neoplasm
Pathways
- Pathogenesis
- Localization
- Methylation
- Cell Proliferation
- Cell Cycle
- Dna Methylation
- Cell Growth
- Cell Migration
- Cell Differentiation
- Oncogenesis
- Rna Interference
- Cell Activation
- Ossification
PTMs
- Phosphorylation
- Methylation
- Ubiquitination
- Sumoylation
Research Areas
- Apoptosis
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AXIN1
bosterbio.com/bosterbio-gene-info-cards/AXIN1
References
PMID: 9230313 by Zeng L., et al. The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.
PMID: 9920888 by Hsu W., et al. Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.