Akr1c6 Antibodies

AND Akr1c6 ELISA kits, Akr1c6 Proteins

Many biological assays use antibodies to detect Akr1c6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Akr1c6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Akr1c6 antibodies...

We validate the specificity of these antibodies to Akr1c6 by testing them on tissues known to express Akr1c6 positively and negatively. Browse below to find the Akr1c6 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Akr1c6 Infographic by Boster Bio

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Akr1c6 Overview

Facts about Estradiol 17 beta-dehydrogenase 5.

Akr1c6 3D structure. Source: alphafold

Estradiol 17 beta-dehydrogenase 5 (Akr1c6)

Active toward androgens, estrogens, and xenobiotic substrates. Also exhibits low 20 alpha-HSD activity.

Shows a- stereospecificity in hydrogen transfer between cofactors and substrates (A-specific). Preferentially catalyzes the reduction of 4-androstenedione, 5-alpha-androstane-3,17-dione, androsterone and dehydroepiandrosterone to testosterone, dihydrotestosterone, 5- alpha-androstane-3-alpha,17-beta-diol and 5-androstene-3-beta,17- beta-diol, respectively.

Gene Information

Mouse
Gene Name:	Akr1c6
Uniprot:	P70694
Entrez:	83702

Family

Belongs to:

aldo/keto reductase family

Alternative Names

Estradiol 17 beta-dehydrogenase 5

Molecular Weight

Mass (kDA):
37.048 kDA

Genomic Context


Mouse

Location:	13 A1\|13 2.48 cM
Sequence:	13;

Tissue Specificity

Mainly found in liver. Also expressed weakly in kidney.

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Akr1c6

References

PMID: 7737980 by Deyashiki Y., et al. Molecular cloning and characterization of mouse estradiol 17 beta- dehydrogenase (A-specific), a member of the aldoketoreductase family.

PMID: 10500239 by Rheault P., et al. Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene.