Apela Antibodies

AND Apela ELISA kits, Apela Proteins

Many biological assays use antibodies to detect Apela, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Apela in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Apela antibodies...

We validate the specificity of these antibodies to Apela by testing them on tissues known to express Apela positively and negatively. Browse below to find the Apela antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Apela Infographic by Boster Bio

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Apela Overview

Facts about Apelin receptor early endogenous ligand.

Apelin receptor early endogenous ligand (Apela)

Endogenous ligand for the apelin receptor (APLNR) (By similarity). Hormone required for mesendodermal distinction, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis (PubMed:28371822, PubMed:28854362, PubMed:28890073, PubMed:28663440).

Drives internalization of the APLNR (By similarity). Acts as a motogen by boosting mesendodermal cell migration during gastrulation by binding and activating APLNR (By similarity).

Gene Information

Mouse
Gene Name:	Apela
Uniprot:	P0DMC4
Entrez:	100038489

Family

Belongs to:

Elabela/Toddler family

Alternative Names

Apelin receptor early endogenous ligand

Molecular Weight

Mass (kDA):
6.828 kDA

Genomic Context


Mouse

Location:	8 B3.1\|8
Sequence:	8;

Tissue Specificity

Expressed in the placenta (PubMed:28663440). Expressed in syncytiotrophoblasts of the placenta labyrinth at 10.5 dpc (PubMed:28663440). Expressed in placental chorionic trophoblasts (at protein level) (PubMed:28663440). Expressed in a small population of epiblast cells in the distal half of the embryo at 7 dpc (PubMed:20153842, PubMed:28854362). Expressed in newly formed definitive endoderm cells in the proximal half of the embryo, while it is not present in extra-embryonic endoderm at 7.5 dpc (PubMed:20153842, PubMed:28854362). This expression pattern then changes to the ventral aspect of the developing foregut pocket and the entire hindgut pocket at 8.5 dpc, before becoming restricted to the foregut overlying the heart and the posterior- most hindgut (PubMed:20153842). Not detected in endothelial precursor cells of the yolk sac at 8 dpc (PubMed:28663440). Expressed in extraembryonic tissues as well as in the chorion at 8.25 dpc (PubMed:28854362). Expressed in endometrial stroma of the uterus of pregnant mice at 8.5 dpc (PubMed:28663440). Expressed in the developing heart, caudal neural tube and trophobasts at 9 dpc (PubMed:28663440). Expressed in the chorionic plate of the chorio

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Apela

References

PMID: 20153842 by Hassan A.S., et al. Expression of two novel transcripts in the mouse definitive endoderm.

PMID: 26611206 by Perjes A., et al. Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart.