Ataxin-7-like protein 3B (Atxn7l3b)

By binding to ENY2, interferes with the atomic functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by altering the subcellular distribution of ENY2 and altering ENY2 accessibility for ATXN7L3 interaction.

Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 leading to loss of atomic ENY2-ATXN7L3 institution which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3.