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- Table of Contents
Facts about Beta-1,4-N-acetylgalactosaminyltransferase 3.
Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and Likely O-linked glycans.
Mediates the N,N'- diacetyllactosediamine formation on gastric mucosa..
| Human | |
|---|---|
| Gene Name: | B4GALNT3 |
| Uniprot: | Q6L9W6 |
| Entrez: | 283358 |

| Belongs to: |
|---|
| chondroitin N-acetylgalactosaminyltransferase family |

B4GalNAcT3; B4GALNT3; beta-1,4-N-acetyl-galactosaminyl transferase 3; beta-1,4-N-acetylgalactosaminyltransferase III; Beta4GalNAcT3; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase; NGalNAc-T2
Mass (kDA):
114.975 kDA

| Human | |
|---|---|
| Location: | 12p13.33 |
| Sequence: | 12; NC_000012.12 (459939..563509) |
Highly expressed in testis, colon and stomach. Weakly expressed in other tissues.
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Localizes to apical Golgi.




PMID: 12966086 by Sato T., et al. Molecular cloning and characterization of a novel human beta 1,4-N- acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.
PMID: 16728562 by Ikehara Y., et al. Apical Golgi localization of N,N'-diacetyllactosediamine synthase, beta4GalNAc-T3, is responsible for LacdiNAc expression on gastric mucosa.