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- Table of Contents
Facts about B melanoma antigen 1.
Unknown.
Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes..
| Human | |
|---|---|
| Gene Name: | BAGE |
| Uniprot: | Q13072 |
| Entrez: | 574 |

| Belongs to: |
|---|
| BAGE family |

B melanoma antigen 1
Mass (kDA):
4.81 kDA

| Human | |
|---|---|
| Location: | 21p11.1 |
| Sequence: | 21; |
Not expressed in normal tissues, except in testis. Expressed with significant proportion in melanomas, but also in tumors of various histological origins, such as bladder carcinomas, head and neck squamous cell carcinomas, lung and breast carcinomas. Not expressed in renal, colorectal and prostatic carcinomas, leukemias and lymphomas. More frequently expressed in metastatic melanomas than in primary melanomas.
Secreted.


PMID: 7895173 by Boel P., et al. BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes.
PMID: 12461691 by Ruault M., et al. New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile.