This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
BCCIP Antibodies
AND BCCIP ELISA kits, BCCIP Proteins
Many biological assays use antibodies to detect BCCIP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BCCIP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BCCIP antibodies...
Previous: Septin9
Next: EIF5A2
BCCIP Infographic by Boster Bio
All BCCIP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05912-2
100 µg/vial
Cat # A05912-2
100 µg/vial
BCCIP Overview
Facts about BRCA2 and CDKN1A-interacting protein.
BRCA2 and CDKN1A-interacting protein (BCCIP)
During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and insertion of the spindle pole (PubMed:28394342).
Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A.
Gene Information
| Human | |
|---|---|
| Gene Name: | BCCIP |
| Uniprot: | Q9P287 |
| Entrez: | 56647 |
Family
| Belongs to: |
|---|
| BCP1 family |
Alternative Names
BCCIPalpha; BRCA2 and CDKN1A interacting protein; BRCA2 and CDKN1A-interacting protein; BRCA2 and Cip1/p21 interacting protein; cdk inhibitor p21 binding protein; P21- and CDK-associated protein 1; Protein TOK-1; TOK-1; TOK-1alpha; TOK1BCCIPbeta; TOK-1beta
Molecular Weight
Mass (kDA):
35.979 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.2 |
| Sequence: | 10; NC_000010.11 (125823546..125853695) |
Tissue Specificity
Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.
Subcellular Localizations
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Colocalizes with BRCA2 in discrete nuclear foci (PubMed:15713648). In interphase, preferential localizes to the mother centriole (PubMed:28394342). Recruited to the spindle pole matrix and centrosome by microtubules and dynein/dynactin activity (PubMed:28394342).; [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Isoform 1/beta tends to be less abundant at, and less strongly associated with, centroso
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
- Mammary Neoplasms
- Neoplasm Metastasis
- Melanoma
- Carcinoma
- Genomic Instability
- Prostatic Neoplasms
- Glioblastoma
- Laryngeal Squamous Cell Carcinoma
Interacting Proteins
- RPL23
Pathways
- Cell Cycle
- Dna Repair
- Cell Growth
- Rna Interference
- Cell Proliferation
- Dna Replication
- Cell Migration
- Cytokinesis
- Recombinational Repair
- Mitosis
- Localization
- Cell Death
- Cell Cycle Checkpoint
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BCCIP
bosterbio.com/bosterbio-gene-info-cards/BCCIP
References
PMID: 10878006 by Ono T., et al. TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase.
PMID: 12527204 by Meng X., et al. Genomic structure of the human BCCIP gene and its expression in cancer.