BEN domain-containing protein 3 (BEND3)

Transcriptional repressor which partners with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of this NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909).

Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) into major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671).