This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Class E basic helix-loop-helix protein 22.
In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be needed for the survival of a particular population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn which may regulate pruritis.
Human | |
---|---|
Gene Name: | BHLHE22 |
Uniprot: | Q8NFJ8 |
Entrez: | 27319 |
Belongs to: |
---|
No superfamily |
Basic Helix-Loop-Helix Domain Containing, Class B, 5; basic helix-loop-helix family, member e22; Beta3; BHLHE22; CAGL85; Class B Basic Helix-Loop-Helix Protein 5; Class E Basic Helix-Loop-Helix Protein 22; TNRC20; Trinucleotide Repeat Containing 20; Trinucleotide Repeat-Containing Gene 20 Protein
Mass (kDA):
36.997 kDA
Human | |
---|---|
Location: | 8q12.3 |
Sequence: | 8; NC_000008.11 (64580365..64583627) |
Nucleus.
PMID: 12213201 by Xu Z.-P., et al. Functional and structural characterization of the human gene BHLHB5, encoding a basic helix-loop-helix transcription factor.
PMID: 14516699 by McLellan A.S., et al. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.