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- Table of Contents
BLK Antibodies
AND BLK ELISA kits, BLK Proteins
Many biological assays use antibodies to detect BLK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BLK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BLK antibodies...
Designing a Western blot for BLK? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BLK Western Blot GuideBLK Infographic by Boster Bio
All BLK Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A01539
100ul
Cat # A01539
100ul
BLK Overview
Facts about Tyrosine-protein kinase Blk.
Tyrosine-protein kinase Blk (BLK)
Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and related coreceptors.
Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that finally contributes to B-cell activation. Signaling through BLK plays an significant role in transmitting signals through surface immunoglobulins and encourages the pro-B into pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor.
Gene Information
| Human | |
|---|---|
| Gene Name: | BLK |
| Uniprot: | P51451 |
| Entrez: | 640 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
B lymphocyte kinase; B lymphoid tyrosine kinase; BLK nonreceptor tyrosine kinase; Blk; EC 2.7.10.2; MGC10442; MODY11; p55-Blk; tyrosine-protein kinase Blk
Molecular Weight
Mass (kDA):
57.706 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p23.1 |
| Sequence: | 8; NC_000008.11 (11493991..11564599) |
Tissue Specificity
Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.
Subcellular Localizations
Cell membrane; Lipid-anchor. Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity).
Diseases
- Lupus Erythematosus, Systemic
- Neoplasms
- Leukemia
- Lymphoma
- Autoimmune Reaction
- Malignant Neoplasms
- Autoimmune Diseases
- Rheumatoid Arthritis
- Arthritis
- Acute Lymphocytic Leukemia
- Sclerosis
- Diffuse Scleroderma
- B-cell Lymphomas
Interacting Proteins
- AR
- EGFR
- GAB1
- KIT
- STAT3
Pathways
- Pathogenesis
- Cell Development
- Localization
- Cell Death
- Cell Activation
- B Cell Activation
- Cell Proliferation
- Cell Differentiation
- B Cell Proliferation
- B Cell Differentiation
- Transport
- Immune Response
- Cell Cycle
PTMs
- Phosphorylation
- Methylation
- Dephosphorylation
- Cleavage
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BLK
bosterbio.com/bosterbio-gene-info-cards/BLK
References
PMID: 7822795 by Islam K.B., et al. Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.
PMID: 7845672 by Drebin J.A., et al. Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk).