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- Table of Contents
BMPR2 Antibodies
AND BMPR2 ELISA kits, BMPR2 Proteins
Many biological assays use antibodies to detect BMPR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BMPR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BMPR2 antibodies...
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BMPR2 Infographic by Boster Bio
All BMPR2 Products
Product
Figures
Specificity
Applications
Price
Anti-BMPR2 Antibody Picoband®
2 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00324-2
100 μg/vial
Cat # A00324-2
100 μg/vial
BMPR2 Overview
Facts about Bone morphogenetic protein receptor type-2.
Bone morphogenetic protein receptor type-2 (BMPR2)
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.
Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but improved by the presence of type I receptors for BMPs.
Gene Information
| Human | |
|---|---|
| Gene Name: | BMPR2 |
| Uniprot: | Q13873 |
| Entrez: | 659 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
BMP type II receptor; BMP type-2 receptor; BMPR2; BMPR-2; BMPR3; BMPRII; BMPR-II; BMPR-IIprimary pulmonary hypertension 1; Bone morphogenetic protein receptor type II; bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); BRK-3; EC 2.7.11; EC 2.7.11.30; FLJ41585; FLJ76945; PPH1BMR2; T-ALK; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4
Molecular Weight
Mass (kDA):
115.201 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q33.1-q33.2 |
| Sequence: | 2; NC_000002.12 (202376310..202567751) |
Tissue Specificity
Highly expressed in heart and liver.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Hypertensive Disease
- Pulmonary Hypertension
- Idiopathic Pulmonary Hypertension
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Hypertrophy
- Hereditary Hemorrhagic Telangiectasia
- Hypoxia
- Vascular Diseases
- Telangiectasis
Interacting Proteins
- C4bpa
- GDF5
- Prkcb
- PRKG1
Pathways
- Pathogenesis
- Cell Proliferation
- Localization
- Cell Growth
- Cell Differentiation
- Vasoconstriction
- Angiogenesis
- Muscle Cell Proliferation
- Smooth Muscle Cell Proliferation
- Translation
- Regeneration
- Cell Cycle
- Ovulation
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BMPR2
bosterbio.com/bosterbio-gene-info-cards/BMPR2
References
PMID: 7791754 by Liu F., et al. Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
PMID: 7644468 by Rosenzweig B.L., et al. Cloning and characterization of a human type II receptor for bone morphogenetic proteins.
3 Publications of Boster BMPR2 Antibodies & ELISA Kits
- PubMed ID: PMID:26439051, TRAM-34 attenuates hypoxia induced pulmonary artery smooth muscle cell prolifera...
- PubMed ID: 10.1016/j.ecoenv.2020.110930, Benzo[a]pyrene injures BMP2-induced osteogenic differentiation of mesenchymal st...
- PubMed ID: 29512689, MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells i...
*More publications can be found for each product on its corresponding product page