Valacyclovir hydrolase (BPHL)

Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs like valacyclovir and valganciclovir. Activates valacyclovir to acyclovir.

May play a role in detoxification processes. It is a particular alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and doesn't have a stringent requirement for the departing group other than preferring a primary alcohol.