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- Table of Contents
BRCA1-associated protein Antibodies
AND BRAP ELISA kits, BRCA1-associated protein Proteins
Many biological assays use antibodies to detect BRCA1-associated protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BRCA1-associated protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BRCA1-associated protein antibodies...
Designing an IHC experiment for BRCA1-associated protein? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the BRAP IHC GuideBRAP Infographic by Boster Bio
All BRAP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$405
Cat # A03573
100ul
Cat # A03573
100ul
BRAP Overview
Facts about BRCA1-associated protein.
BRCA1-associated protein (BRAP)
Negatively regulates MAP kinase activation by limiting the creation of Raf/MEK complexes likely by inactivation of the KSR1 scaffold protein. Also functions as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is altered by auto- polyubiquitination leading to the release of inhibition of Raf/MEK complex formation.
May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. .
Gene Information
| Human | |
|---|---|
| Gene Name: | BRAP |
| Uniprot: | Q7Z569 |
| Entrez: | 8315 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BRAP2RING finger protein 52; BRCA1 associated protein; EC 6.3.2.-; IMPBRCA1-associated protein; Impedes mitogenic signal propagation; Renal carcinoma antigen NY-REN-63; RNF52galectin-2-binding protein
Molecular Weight
Mass (kDA):
67.305 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.12 |
| Sequence: | 12; NC_000012.12 (111642146..111686023, complement) |
Tissue Specificity
Expressed in breast epithelial cell lines.
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Neoplasms
- Ovarian Neoplasm
- Malignant Neoplasm Of Ovary
- Carcinoma
- Adenocarcinoma
- Infarction
- Myocardial Infarction
- Cell Transformation, Neoplastic
- Brca1 Gene Mutation
- Ductal Breast Carcinoma
Interacting Proteins
- AKAP3
- BRCA1
- HRAS
Pathways
- Dna Repair
- Localization
- Methylation
- Cell Cycle
- Pathogenesis
- Cell Proliferation
- Nuclear Import
- Oncogenesis
- Drug Resistance
- Rna Interference
- Secretion
- Cell Adhesion
- Transport
PTMs
- Methylation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BRAP
bosterbio.com/bosterbio-gene-info-cards/BRAP
References
PMID: 9497340 by Li S., et al. Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs.
PMID: 14724641 by Matheny S.A., et al. Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP.