Phospholipid transfer protein C2CD2L (C2CD2L)

Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5- bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which can be degraded during phospholipase C (PLC) signaling (PubMed:28209843).

Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated in its C- terminus and dissociates in the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843).