Calcineurin-binding protein cabin-1 (CABIN1)

May be required for replication-independent chromatin assembly. May function as a negative regulator of T-cell receptor (TCR) signaling through inhibition of calcineurin.

Inhibition of activated calcineurin depends on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin in promoters of a subset of it's target genes.