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- Table of Contents
CACNA1S Antibodies
AND CACNA1S ELISA kits, CACNA1S Proteins
Many biological assays use antibodies to detect CACNA1S, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CACNA1S in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CACNA1S antibodies...
Designing a Western blot for CACNA1S? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CACNA1S Western Blot GuideCACNA1S Infographic by Boster Bio
All CACNA1S Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A03006-1
100 μg/vial
Cat # A03006-1
100 μg/vial
CACNA1S Overview
Facts about Voltage-dependent L-type calcium channel subunit alpha-1S.
Voltage-dependent L-type calcium channel subunit alpha-1S (CACNA1S)
Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an significant role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately leads to muscle contraction.
Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CACNA1S |
| Uniprot: | Q13698 |
| Entrez: | 779 |
Family
| Belongs to: |
|---|
| calcium channel alpha-1 subunit (TC 1.A.1.11) family |
Alternative Names
CACH1; CACN1; CACNL1A3MHS5; calcium channel, L type, alpha 1 polypeptide, isoform 3 (skeletal muscle; Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; calcium channel, voltage-dependent, L type, alpha 1S subunit; Cav1.1; CCHL1A3; dihydropyridine receptor; dihydropyridine-sensitive L-type calcium channel alpha-1 subunit; HOKPP; HOKPP1; hypokalemic periodic paralysis); hypoPP; TTPP1; voltage-dependent L-type calcium channel subunit alpha-1S; Voltage-gated calcium channel subunit alpha Cav1.1
Molecular Weight
Mass (kDA):
212.35 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.1 |
| Sequence: | 1; NC_000001.11 (201039509..201112453, complement) |
Tissue Specificity
Skeletal muscle specific.
Subcellular Localizations
Cell membrane, sarcolemma, T-tubule; Multi-pass membrane protein.
Diseases
- Hypokalemic Periodic Paralysis
- Periodic Paralysis (finding)
- Malignant Hyperpyrexia Due To Anesthesia
- Malignant Paraganglionic Neoplasm
- Weakness
- Muscle Weakness
- Myopathy
- Hyperkalemic Periodic Paralysis
- Thyrotoxicosis
- Channelopathies
- Thyrotoxic Periodic Paralysis
- Familial Periodic Paralysis
- Central Core Myopathy (disorder)
Interacting Proteins
- PDZD3
Pathways
- Muscle Contraction
- Pathogenesis
- Diaphragm Development
- Tissue Development
- Membrane Depolarization
- Skeletal Muscle Contraction
- Immune Response
- Response To Caffeine
- Muscle Atrophy
PTMs
- Disulfide bond
Research Areas
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CACNA1S
bosterbio.com/bosterbio-gene-info-cards/CACNA1S
References
PMID: 7713519 by Hogan K., et al. Cloning of the human skeletal muscle alpha 1 subunit of the dihydropyridine-sensitive L-type calcium channel (CACNL1A3).
PMID: 8838325 by Hogan K., et al. The structure of the gene encoding the human skeletal muscle alpha 1 subunit of the dihydropyridine-sensitive L-type calcium channel (CACNL1A3).