Caprin-2 Antibodies

AND CAPRIN2 ELISA kits, Caprin-2 Proteins

Many biological assays use antibodies to detect Caprin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Caprin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Caprin-2 antibodies...

We validate the specificity of these antibodies to Caprin-2 by testing them on tissues known to express CAPRIN2 positively and negatively. Browse below to find the CAPRIN2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CAPRIN2 Infographic by Boster Bio

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CAPRIN2 Overview

Facts about Caprin-2.

CAPRIN2 3D structure. Source: alphafold

Caprin-2 (CAPRIN2)

Promotes phosphorylation of the Wnt coreceptor LRP6, resulting in increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Faciliates constitutive LRP6 phosphorylation by CDK14/CCNY through G2/M stage of the cell cycle, which might potentiate cells for Wnt signaling (PubMed:27821587).

May regulate the transport and translation of mRNAs, regulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth since erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112).

Gene Information

Human
Gene Name:	CAPRIN2
Uniprot:	Q6IMN6
Entrez:	65981

Family

Belongs to:

caprin family

Alternative Names

caprin family member 2; FLJ22569; RNA granule protein 140

Molecular Weight

Mass (kDA):
125.925 kDA

Genomic Context


Human

Location:	12p11.21
Sequence:	12; NC_000012.12 (30709552..30754993, complement)

Tissue Specificity

Detected in all tissues tested with highest levels of expression in brain and spleen.

Subcellular Localizations

[Isoform 1]: Cytoplasm.; [Isoform 2]: Mitochondrion. Cytoplasm. Expressed throughout the cytoplasm.; [Isoform 5]: Mitochondrion. Colocalizes with aggregated mitochondria.; Cell membrane; Peripheral membrane protein.

Diseases

Leukemia
Monocytic Leukemia

Interacting Proteins

LRP5
PEX5

Pathways

Lens Fiber Cell Differentiation
Cell Cycle
Signal Transmission
Cell Differentiation
Viral Latency

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CAPRIN2

References

PMID: 14593112 by Aerbajinai W., et al. Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth.

PMID: 14764709 by Grill B., et al. Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins.